Green Cross

Origin of Yangcheng
Origin of Yangcheng,A Fusion of East and West

In 1991, Guangzhou Baiyunshan Qiaoguang Pharmaceutical Factory joined forces with Japanese partners to plant its first seed in the fertile soil of Lingnan. In the years that followed, as a wholly-owned subsidiary of Mitsubishi Tanabe Pharma (ranked among the world’s top 50 pharmaceutical companies) in China, Green Cross was steeped in the Japanese pharmaceutical ethos of “gentleness, stability, and long-termism,” embedding the principle that “quality is life” into every detail of its manufacturing processes. In 2014, Chairman Liang Feng led his team in completing a full acquisition, ushering in a new era characterized by “Japanese excellence on the outside and Chinese dynamism on the inside”—preserving tradition while embracing innovation.

Origin of Yangcheng
Three Decades of Experience, Dual-Drive Strategy

Over the past three decades, Green Cross has cultivated a dual DNA of “innovation and generic drug development,” holding 59 drug approvals:

Amino Acids: The company established its industry-leading position by launching several domestically pioneering amino acid formulations;

Bioequivalence Evaluation: Proactively embracing national centralized procurement, seven products have successfully won bids, covering 32 provinces and municipalities nationwide, thereby generating strong cash flow to fuel the next wave of innovation.

We firmly believe: We hone our sword through generic drugs and forge ahead toward innovation; every step we take in following the trend paves the way for our future leadership. We forge our spirit through innovation and dedicate ourselves to health, transforming every spark of inspiration into well-being for millions of households.

Origin of Yangcheng
Integrating R&D, Production, and Sales: A Closed-Loop Approach to Success

2 major R&D centers

4 major marketing centers

5 major manufacturing bases

We have established a fully integrated, end-to-end process spanning from molecular discovery to patient access, ensuring that every tablet reaches the clinical front lines with maximum efficiency and at optimal cost.

Origin of Yangcheng
An Engine of Innovation, Looking Toward the Future

A pipeline of 11 candidates, focusing on major diseases such as metabolic and autoimmune disorders;

GCF20211, GCF20212, and GCF20215 have entered the IND application drafting phase, with five animal studies proceeding in parallel;

With over 150 R&D professionals led by senior scientists from China and abroad, we are collaborating closely with top institutions such as Zhejiang University, Shenyang Pharmaceutical University, the University of California, and University College London to build an open and collaborative innovation ecosystem.

Origin of Yangcheng
An Elite Team, Open to Diversity

Our core management team has an average of over 20 years of industry experience, combining the rigor of foreign-funded companies with the strategic vision of state-owned enterprises and the agility of local firms;

Culturally, we uphold the Japanese values of “moderation and stability” while integrating local traits of “ambition, efficiency, pragmatism, and inclusivity,” enabling talent from diverse backgrounds to thrive together at Green Cross.

Origin of Yangcheng
Vision and Mission

Guided by our core values of “Protecting Life, Pursuing Excellence, and Integrity and Pragmatism,” we focus on major diseases that threaten human health and are committed to becoming a trusted guardian of a healthy China and a leading domestic research-based pharmaceutical company.

ABOUT US

Company Profile
Green Cross Pharmaceutical Co., Ltd.

Founded in 1991 and located in Guangzhou—the birthplace of Guangfu culture—Guangzhou Green Cross Pharmaceutical is a comprehensive pharmaceutical enterprise primarily engaged in the research, development, production, and sales of high-end parenteral nutrition products and a wide range of chemical pharmaceuticals. The company has established a closed-loop industrial chain, featuring its own comprehensive production, R&D, and sales systems, as well as a wholly-owned R&D subsidiary (Saifeng Pharmaceutical), a majority-owned production subsidiary (Huineng Pharmaceutical), and a wholly-owned sales subsidiary (Kemao Pharmaceutical). In 2021, the company established Shandong Haorui’en and Guangdong Haorui’en, creating two major production bases in Shandong and Qingyuan.  

 

Green symbolizes peace and prosperity, while the cross symbolizes love for humanity. APAM stands for “Medical Servant”; serving the medical field is both the founding principle of Green Cross and the mission of its people. Since its inception, the company has upheld its mission as a medical service provider, prioritizing R&D and placing people at the heart of its pharmaceutical operations. It was certified as a “Guangdong Provincial High-Tech Enterprise” from 2018 to 2021. The company focuses on recruiting high-caliber pharmaceutical talent and upgrading its product portfolio, transforming from a leading amino acid manufacturer into a comprehensive chemical pharmaceutical enterprise dedicated to innovation and high-end generic drug development. In 2021, the company secured nearly 300 mu of newly planned land, striving to become one of the most respected pharmaceutical companies.

 

We sincerely invite capable and visionary colleagues from the domestic pharmaceutical industry to become our strategic partners. Let us join hands to make greater contributions to the development of the industry and public health, and together create a brighter future.

35

Year
Focus on Pharmaceutical Manufacturing

2

Major
R&D Center

4

Major
Marketing Center

5

Major
Manufacturing Facility

Honor
Member Organizations

Pharmaceutical Chamber of Commerce of the All-China Federation of Industry and Commerce

High-Tech Enterprise

Department of Science and Technology of Guangdong Province
Department of Finance of Guangdong Province
Guangdong Provincial Tax Bureau of the State Taxation Administration

Specialized, Innovative, and New SMEs

Department of Industry and Information Technology of Guangdong Province

Member Organizations

Over-the-counter Medications In China

Member Organizations

Guangdong Association of Innovative Biomedical Technologies

Member Organizations

Guangzhou Development Zone Association for the Promotion of Enterprise Listings and the New Third Board

High-Tech Enterprise

Guangzhou Saifeng Pharmaceutical Technology Co., Ltd.

Guangzhou's New “Little Giants” in Science and Technology

Guangzhou Saifeng Pharmaceutical Technology Co., Ltd.

Joint Research Center for Advanced Formulations

Zhejiang University–Guangzhou Green Cross Pharmaceutical

Research and Development Institutions of Enterprises in Guangzhou

Guangzhou Municipal Commission of Science and Technology Innovation

Practicum Training Site

Guangzhou Medical University

Provincial Enterprise Technology Center

Department of Industry and Information Technology of Guangdong Province

Core Team
Chairman/General Manager
Liang Feng

With nearly 30 years of experience in the pharmaceutical industry, he possesses a deep understanding of the development paths of pharmaceutical companies. He established ShuaiKe’s R&D system, and the clopidogrel he led in developing continues to generate annual revenue of over 1 billion yuan and net profits exceeding 400 million yuan even after being acquired by Lepu; he has extensive experience in the management and operations of pharmaceutical companies.

Vice President
Hu Gongyun

With nearly 40 years of experience in the pharmaceutical industry, he is a professor-level senior engineer; he has received two Second Prizes of the National Science and Technology Progress Award, two First Prizes of the Shanghai Science and Technology Progress Award, and one First Prize of the Zhejiang Science and Technology Achievement Transformation Award.

Vice President of Production
Liu Songqiang

With over 30 years of experience in the pharmaceutical industry, he is a Senior Engineer and a Licensed Pharmacist; he has led the completion of dozens of generic drug R&D projects and bioequivalence studies, and has spearheaded multiple major national and provincial-level research initiatives.

Vice President of Sales
Li Hongxia

Over 20 years of sales experience; former Sales Director at Fresenius Kabi (China); has led the sales of multiple products with annual sales exceeding 1 billion yuan in China

General Manager of Research and Development
Wang Duantong

With nearly 30 years of experience in the pharmaceutical industry, he is a Senior Engineer and a Licensed Pharmacist. He previously served as Vice President of the Central Research Institute at Haizheng Pharmaceutical, where he focused extensively on the management of formulation R&D. He has led numerous international formulation projects that have received marketing approval from the FDA, the EU, and the WHO.

Enterprise journal

Introduction to the Corporate Journal: Upholding the philosophy of “Serving Medicine,” Green Cross is committed to contributing to 
the healthcare sector through exceptional pharmaceuticalsand high-quality services.

New Green 2025, Issue 4
New Green Internal Newsletter, Issue 58
New Green 2025, Issue 4

This article focuses on the central theme of “clinical value-driven development of modified new drugs” and is published in two parts. The first part, published previously, systematically analyzed the concept of clinical value and its evaluation framework, providing a scientific foundation for the research. This second part explains the bridging role of clinical pharmacology research to help clarify the fundamental development strategies for different modification approaches.

Issue:2025年12月

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New Green 2025 Issue 4
New Green Internal Newsletter, Issue 57
New Green 2025 Issue 4

In June 2025, we had the honor of inviting Professor Zhang Kejian to our company to discuss the rationale for our ongoing modified new drug projects. This exchange provided us with a profound understanding of the fundamental principles guiding the development of modified new drugs. Drawing on my limited knowledge, I would like to explore with you the research of modified new drugs guided by clinical value. By integrating the latest domestic and international technical guidelines, I will conduct an in-depth analysis of the essence of clinical value and the corresponding development strategies in R&D practice. In its 2024 Annual Drug Review Report, the CDE presented an overview of the registration applications and NDA approvals for modified new drugs in China. As a key direction in drug R&D, the success rate of modified new drug applications has been increasing year by year, and the market for modified new drugs in China is showing strong growth momentum. Modified new drugs are also considered to align with the strategic transformation of China’s pharmaceutical enterprises...

Issue:2025年09月

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New Green 2025 Issue 3
New Green Internal Newsletter, Issue 56
New Green 2025 Issue 3

The successive approvals of the company’s Compound Amino Acid Injection (14AA-SF) and Compound Amino Acid Injection (18AA-SF) mark the domestic launch of a new generation of high-quality compound amino acid products and underscore the Green Cross team’s unwavering commitment to product quality and their dedication to craftsmanship.

Issue:2025年04月

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Milestone

History

1991

A joint venture established by Japan Green Cross, Qiaoguang Pharmaceutical, and Shengyi Trading

2014

Led by Liang Feng, the Chinese-led acquisition resulted in the company being restructured and renamed “Guangzhou Green Cross Pharmaceutical Co., Ltd.”

2017

Received investment from Warburg Pincus (now Hillhouse Capital's U.S. dollar fund)

2018

Established a Joint R&D Center for High-End Pharmaceutical Formulations with Zhejiang University and obtained certification as a high-tech enterprise.

2021

Green Cross officially completed its shareholding restructuring; received approval for eight products, two of which were selected in the fifth round of the national centralized procurement; established a production base in Shandong in the same year.

2022

Established a production base in Qingyuan; obtained approval for four products; among them, Fluvoxamine Maleate Tablets were selected in the seventh round of the National Centralized Procurement.

2023

Established an active pharmaceutical ingredient (API) production base in Shandong; obtained approval for 13 products; two of these products were selected in the ninth round of the national centralized procurement program

2024

Ten products have been approved; among them, two products were selected in the 10th round of the national centralized procurement.

2025

The Group has been approved for a total of 14 projects, including 4 APIs and 10 finished dosage forms; Guangdong Province Famous and Excellent High-Tech Product (18AA-SF); Certificate of Filing for the National Pilot Platform for Patent-Intensive Product Filing and Certification; Guangzhou City Innovative Product (18AA-SF); 2025 8th Guangdong-Hong Kong-Macao Greater Bay Area Top 50 Biotech Innovation Enterprises – Leading Enterprise; 2025 Top 500 Manufacturing Enterprises in Guangdong Province; Guangdong Provincial Enterprise Technology Center. Clinical trials for the expanded indications of Dolisun have concluded, demonstrating significant efficacy.

 

The Qingyuan Haorui’en production base and the Shandong Rui’en Biotechnology production base have been completed and obtained production licenses, with two projects submitted for registration.

 

Hainan Huineng has been recognized as a Specialized, Refined, Unique, and Innovative SME, designated as a Hainan Provincial Green Factory, and has passed the National Certification for Science and Technology-Based SMEs and the Enterprise R&D Institution Certification.

 

Shandong Haorui’en officially commenced production and was recognized as a National Technology-Based SME; Zhu Zhonghua, Vice Chairman of the Heze Municipal Committee of the Chinese People’s Political Consultative Conference and Secretary of the Party Working Committee of Luxi New District, visited Shandong Haorui’en for an on-site inspection; the Heze Branch Center passed the 18AA-VII B license inspection conducted by the Shandong Provincial Drug Administration; and the facility passed the GMP compliance inspection by the Shandong Provincial Food and Drug Evaluation and Inspection Center.